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The Oklahoma Sooners (1-1) will take on the Iowa State Cyclones (1-1) Saturday at Jack Trice Stadium for a 7:30 p.m. ET kickoff. We analyze the Oklahoma-Iowa State college football betting odds and lines, with picks and best bets.

The Sooners are ranked 16th in the Amway Coaches Poll.

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Oklahoma at Iowa State: Betting odds and lines

Odds via BetMGM; access USA TODAY Sports’ betting odds for a full list. Lines last updated Friday at 2:15 p.m. ET.

Money line: Oklahoma -278 (bet $278, win $100) Iowa State +220 (bet $100, win $220)Against the spread/ATS: Oklahoma -7 (-110) Iowa State +7 (-110)Over/Under: 63.5 (O: -110 U: -110)

Oklahoma at Iowa State: Three things to know

Oklahoma is averaging 7.65 yards per play this season. That is the sixth-best in the country this year.Iowa State has allowed a combined 65 points to TCU and Lousiana. The Cyclones are also allowing 277 passing yards per game, which is among the worst in college football.Oklahoma won 19 of its last 20 games on the road.

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Oklahoma at Iowa State: Odds, betting lines and picks

Prediction

Oklahoma 38, Iowa State 28

Casino House Odds

Money line (ML)

OKLAHOMA (-278) is a big road favorite over Iowa State in this Big 12 contest. The Sooners are coming off a tough loss to Kansas State despite scoring 35 points. They will look to bounce back against a shaky Iowa State team that has struggled mightily at home against Oklahoma.

The Cyclones have lost their last eight games versus the Sooners at Jack Trice Stadium. While a few of those games have been close, most have been blowouts. Expect Oklahoma to win by a couple scores.

Against the spread (ATS)

OKLAHOMA -7 (-110) is a touchdown favorite over Iowa State Saturday evening. Neither team has fared well lately against the spread, as the Sooners have covered just twice in their last nine games. Somehow, Iowa State has been worse, failing to cover the spread in six straight contests.

With this spread being only a touchdown, expect the Sooners to cover here as they should win by double digits. Their offense matches up well against a weak Cyclones’ secondary and QB Spencer Rattler should have a monster performance. Take Oklahoma to win by at least 8 points with confidence.

Over/Under (O/U)

The total for this Big 12 matchup is set at 63.5 points and that still doesn’t feel high enough. Oklahoma can obviously put up a ton of points and is facing one of the worst defenses in the conference in Iowa State. Expect both teams to approach 30 or more points in this one with Oklahoma potentially reaching the 40s. This looks to be another high-scoring contest and the OVER 63.5 (-110) should have no problem hitting in Iowa.

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Also see:

Oklahoma dominant against Iowa State in series history (Sooners Wire)

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